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GCK Matched Antibody Pair (475) (APMAB-475LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-GCK polyclonal antibody, 100 ug
Detection Antibody
Anti-GCK Biotinylated rabbit polyclonal antibody, ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]
Alternative Names
Glucokinase; Glucokinase (Hexokinase 4); Hexokinase Type IV; HK IV; HK4; Maturity Onset Diabetes Of The Young 2; ATP:D-Hexose 6-Phosphotransferase; Hexokinase D, Pancreatic Isozyme; Hexokinase 4; Hexokinase-4; Hexokinase-D;
Entrez Gene ID
2645
UniProt ID
P35557
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For research use only. Not intended for any clinical use.

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