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FOXP3 Matched Antibody Pair (451) (APMAB-451LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-FOXP3 polyclonal antibody, 100 ug
Detection Antibody
Anti-FOXP3 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Alternative Names
Forkhead Box P3; Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked; Scurfin; IPEX; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked; Forkhead Box Protein P3; FOXP3delta7;
Entrez Gene ID
50943
UniProt ID
Q9BZS1
More Infomation

Wang, J., Gong, R., Zhao, C., Lei, K., Sun, X., & Ren, H. (2022). Human FOXP3 and tumour microenvironment. Immunology.

Kressler, C., Gasparoni, G., Nordström, K., Hamo, D., Salhab, A., Dimitropoulos, C., ... & Polansky, J. K. (2021). Targeted de-methylation of the FOXP3-TSDR is sufficient to induce physiological FOXP3 expression but not a functional treg phenotype. Frontiers in Immunology, 11, 609891.

Cortez, J. T., Montauti, E., Shifrut, E., Gatchalian, J., Zhang, Y., Shaked, O., ... & Fang, D. (2020). CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature, 582(7812), 416-420.

Charbonnier, L. M., Cui, Y., Stephen-Victor, E., Harb, H., Lopez, D., Bleesing, J. J., ... & Chatila, T. A. (2019). Functional reprogramming of regulatory T cells in the absence of Foxp3. Nature immunology, 20(9), 1208-1219.

Jia, H., Qi, H., Gong, Z., Yang, S., Ren, J., Liu, Y., ... & Chen, G. G. (2019). The expression of FOXP3 and its role in human cancers. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1871(1), 170-178.

Georgiev, P., Charbonnier, L. M., & Chatila, T. A. (2019). Regulatory T cells: the many faces of Foxp3. Journal of clinical immunology, 39, 623-640.

Deng, G., Song, X., Fujimoto, S., Piccirillo, C. A., Nagai, Y., & Greene, M. I. (2019). Foxp3 post-translational modifications and Treg suppressive activity. Frontiers in immunology, 10, 2486.

Bacchetta, R., Barzaghi, F., & Roncarolo, M. G. (2018). From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation. Annals of the New York Academy of Sciences, 1417(1), 5-22.

Li, X., Gao, Y., Li, J., Zhang, K., Han, J., Li, W., ... & Zhang, C. (2018). FOXP3 inhibits angiogenesis by downregulating VEGF in breast cancer. Cell death & disease, 9(7), 744.

Mailer, R. K. (2018). Alternative splicing of FOXP3—Virtue and vice. Frontiers in immunology, 9, 530.

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For research use only. Not intended for any clinical use.

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