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FGA Matched Antibody Pair (425) (APMAB-425LY)

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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-FGA monoclonal antibody, 100 ug
Detection Antibody
Anti-FGA Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]
Alternative Names
Fibrinogen Alpha Chain; Fibrinogen, A Alpha Polypeptide; Fib2;
Entrez Gene ID
UniProt ID
More Infomation

Li, X., Liu, Y., Cheng, J., Xia, Y., Fan, K., Liu, Y., & Liu, P. F. (2022). Identification and expression analysis of a fibrinogen alpha chain-like gene in Atlantic salmon (Salmo salar). Aquaculture Reports, 22, 100919.

Rezaei-Tavirani, M., Nejad, M. R., Arjmand, B., Tavirani, S. R., Razzaghi, M., & Mansouri, V. (2021). Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis. Archives of Academic Emergency Medicine, 9(1).

Liu, L., Song, J., Li, J., Huang, N., Yang, J., Hu, S., ... & Wang, W. (2020). Isoform 1 of Fibrinogen Alpha Chain Precursor is a Potential Biomarker for Steroid‐Induced Osteonecrosis of the Femoral Head. PROTEOMICS–Clinical Applications, 14(6), 1900099.

Wang, M., Zhang, G., Zhang, Y., Cui, X., Wang, S., Gao, S., ... & Liu, R. (2020). Fibrinogen alpha chain knockout promotes tumor growth and metastasis through integrin–AKT signaling pathway in lung cancer. Molecular Cancer Research, 18(7), 943-954.

Li, H., Ma, R. Q., Cheng, H. Y., Ye, X., Zhu, H. L., & Chang, X. H. (2020). Fibrinogen alpha chain promotes the migration and invasion of human endometrial stromal cells in endometriosis through focal adhesion kinase/protein kinase B/matrix metallopeptidase 2 pathway. Biology of Reproduction, 103(4), 779-790.

Chen, Y., Li, H., Cheng, H. Y., Rui-Qiong, M., Ye, X., Cui, H., ... & Chang, X. H. (2019). Fibrinogen alpha chain is up-regulated and affects the pathogenesis of endometriosis. Reproductive BioMedicine Online, 39(6), 893-904.

Chapman, J., & Dogan, A. (2019). Fibrinogen alpha amyloidosis: insights from proteomics. Expert review of proteomics, 16(9), 783-793.

Wypasek, E., Klukowska, A., Zdziarska, J., Zawilska, K., Treliński, J., Iwaniec, T., ... & Undas, A. (2019). Genetic and clinical characterization of congenital fibrinogen disorders in Polish patients: Identification of three novel fibrinogen gamma chain mutations. Thrombosis Research, 182, 133-140.

Salomon, O., Barel, O., Eyal, E., Ganor, R. S., Kleinbaum, Y., & Shohat, M. (2019). c. 259A> C in the fibrinogen gene of alpha chain (FGA) is a fibrinogen with thrombotic phenotype. The Application of Clinical Genetics, 12, 27.

Cai, R., Li, Y., Wang, W., Gao, X., Liu, M., Diao, Y., ... & Feng, Q. (2018). A novel fibrinogen variant in a Chinese pedigree with congenital dysfibrinogenemia caused by FGA P. Arg38Thr mutation: a case report. Medicine, 97(40).

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For research use only. Not intended for any clinical use.

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