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EPHA2 Matched Antibody Pair (384) (APMAB-384LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-EPHA2 polyclonal antibody, 100 ug
Detection Antibody
Anti-EPHA2 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
Alternative Names
EPH Receptor A2; Tyrosine-Protein Kinase Receptor ECK; EC 2.7.10.1; ECK; Epithelial Cell Receptor Protein Tyrosine Kinase; Ephrin Type-A Receptor 2; Soluble EPHA2 Variant 1; Epithelial Cell Kinase;
Entrez Gene ID
1969
UniProt ID
P29317
More Infomation

Wallaschek, N., Reuter, S., Silkenat, S., Wolf, K., Niklas, C., Kayisoglu, Ö., ... & Bartfeld, S. (2021). Ephrin receptor A2, the epithelial receptor for Epstein-Barr virus entry, is not available for efficient infection in human gastric organoids. PLoS pathogens, 17(2), e1009210.

Wang, H., & Qiu, W. (2021). EPHA2, a promising therapeutic target for hepatocellular carcinoma. Molecular & Cellular Oncology, 8(3), 1910009.

Ieguchi, K., & Maru, Y. (2019). Roles of EphA1/A2 and ephrin‐A1 in cancer. Cancer science, 110(3), 841-848.

Chen, J., Sathiyamoorthy, K., Zhang, X., Schaller, S., Perez White, B. E., Jardetzky, T. S., & Longnecker, R. (2018). Ephrin receptor A2 is a functional entry receptor for Epstein–Barr virus. Nature microbiology, 3(2), 172-180.

Peng, Q., Chen, L., Wu, W., Wang, J., Zheng, X., Chen, Z., ... & Ma, J. (2018). EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer. Cell death & disease, 9(12), 1-16.

Zhang, H., Li, Y., Wang, H. B., Zhang, A., Chen, M. L., Fang, Z. X., ... & Zeng, M. S. (2018). Ephrin receptor A2 is an epithelial cell receptor for Epstein–Barr virus entry. Nature microbiology, 3(2), 1-8.

Qazi, M. A., Vora, P., Venugopal, C., Adams, J., Singh, M., Hu, A., ... & Singh, S. K. (2018). Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent GlioblastomaTargeting EphA2 and EphA3 in Recurrent GBM. Cancer Research, 78(17), 5023-5037.

Langlois, A. C., Marinach, C., Manzoni, G., & Silvie, O. (2018). Plasmodium sporozoites can invade hepatocytic cells independently of the Ephrin receptor A2. PLoS One, 13(7), e0200032.

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For research use only. Not intended for any clinical use.

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