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ENG Matched Antibody Pair (376) (APMAB-376LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-ENG polyclonal antibody, 100 ug
Detection Antibody
Anti-ENG Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Alternative Names
Endoglin; CD105 Antigen; END; Osler-Rendu-Weber Syndrome 1; HHT1; ORW1;
Entrez Gene ID
2022
UniProt ID
P17813
More Infomation

Vicen, M., Igreja Sá, I. C., Tripská, K., Vitverová, B., Najmanová, I., Eissazadeh, S., ... & Nachtigal, P. (2021). Membrane and soluble endoglin role in cardiovascular and metabolic disorders related to metabolic syndrome. Cellular and Molecular Life Sciences, 78(6), 2405-2418.

Tual-Chalot, S., Garcia-Collado, M., Redgrave, R. E., Singh, E., Davison, B., Park, C., ... & Arthur, H. M. (2020). Loss of endothelial endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signaling. Circulation research, 126(2), 243-257.

Singh, E., Redgrave, R. E., Phillips, H. M., & Arthur, H. M. (2020). Arterial endoglin does not protect against arteriovenous malformations. Angiogenesis, 23(4), 559-566.

Rossi, E., Bernabeu, C., & Smadja, D. M. (2019). Endoglin as an adhesion molecule in mature and progenitor endothelial cells: a function beyond TGF-β. Frontiers in Medicine, 6, 10.

Meurer, S., Wimmer, A. E., van de Leur, E., & Weiskirchen, R. (2019). Endoglin trafficking/exosomal targeting in liver cells depends on N-glycosylation. Cells, 8(9), 997.

Lawera, A., Tong, Z., Thorikay, M., Redgrave, R. E., Cai, J., van Dinther, M., ... & Li, W. (2019). Role of soluble endoglin in BMP9 signaling. Proceedings of the National Academy of Sciences, 116(36), 17800-17808.

Puerto-Camacho, P., Amaral, A. T., Lamhamedi-Cherradi, S. E., Menegaz, B. A., Castillo-Ecija, H., Ordóñez, J. L., ... & de Álava, E. (2019). Preclinical Efficacy of Endoglin-Targeting Antibody–Drug Conjugates for the Treatment of Ewing SarcomaOMTX703 Targets Endoglin in Ewing Sarcoma. Clinical Cancer Research, 25(7), 2228-2240.

Vicen, M., Vitverova, B., Havelek, R., Blazickova, K., Machacek, M., Rathouska, J., ... & Nachtigal, P. (2019). Regulation and role of endoglin in cholesterol‐induced endothelial and vascular dysfunction in vivo and in vitro. The FASEB Journal, 33(5), 6099-6114.

Yang, X., Zhao, J., Duan, S., Hou, X., Li, X., Hu, Z., ... & Lu, X. (2019). Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers. Theranostics, 9(14), 4066.

Sugden, W. W., & Siekmann, A. F. (2018). Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia. Current opinion in hematology, 25(3), 237-244.

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For research use only. Not intended for any clinical use.

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