DUSP9 Matched Antibody Pair (354) (APMAB-354LY)

Name: DUSP9 Matched Antibody Pair (354)
SKU: APMAB-354LY
Rating: 5 (1 reviews)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-DUSP9 monoclonal antibody, 100 ug

Detection Antibody

Anti-DUSP9 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Alternative Names

Dual Specificity Phosphatase 9; Map Kinase Phosphatase 4; Mitogen-Activated Protein Kinase Phosphatase 4; MKP-4; MKP4; Serine/Threonine Specific Protein Phosphatase; Dual Specificity Protein Phosphatase 9; EC 3.1.3.16; EC 3.1.3.48;

Entrez Gene ID

1852

UniProt ID

Q99956

More Infomation

References

Khoubai, F. Z., & Grosset, C. F. (2021). DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases. International Journal of Molecular Sciences, 22(21), 11538.

Chen, K., Gorgen, A., Ding, A., Du, L., Jiang, K., Ding, Y., ... & Ghanekar, A. (2021). Dual‐Specificity Phosphatase 9 Regulates Cellular Proliferation and Predicts Recurrence after Surgery in Hepatocellular Carcinoma. Hepatology communications, 5(7), 1310-1328.

Jiang, L., Ren, L., Guo, X., Zhao, J., Zhang, H., Chen, S., ... & Xia, J. (2021). Dual-specificity phosphatase 9 protects against cardiac hypertrophy by targeting ASK1. International Journal of Biological Sciences, 17(9), 2193.

Acharya, S., Dutta, S., Mudrale, S. P., & Bose, K. (2020). Dual specificity phosphatase 9: A novel binding partner cum substrate of proapoptotic serine protease HtrA2. Biochemical and Biophysical Research Communications, 533(3), 607-612.

Ye, P., Xiang, M., Liao, H., Liu, J., Luo, H., Wang, Y., ... & Xia, J. (2019). Dual‐specificity phosphatase 9 Protects against nonalcoholic fatty liver disease in mice through ASK1 suppression. Hepatology, 69(1), 76-93.

Wei, Q., Pu, X., Zhang, L., Xu, Y., Duan, M., & Wang, Y. (2019). Expression of dual-specificity phosphatase 9 in placenta and its relationship with gestational diabetes mellitus. Journal of Diabetes Research, 2019.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rabbit Anti-DUSP9 Recombinant Antibody (EG1008)

Mouse Anti-DUSP9 Recombinant Antibody (2E3)

Mouse Anti-DUSP9 Recombinant Antibody (CBFYM-1080)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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