Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

DSC2 Matched Antibody Pair (352) (APMAB-352LY)


See all DSC2 antibodies
Online Inquiry

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-DSC2 monoclonal antibody, 100 ug
Detection Antibody
Anti-DSC2 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Alternative Names
Desmocollin 2; Cadherin Family Member 2; CDHF2; DSC3; Desmosomal Glycoprotein II/III; Desmosomal Glycoprotein III; Desmosomal Glycoprotein II;
Entrez Gene ID
1824
UniProt ID
Q02487
More Infomation

Raya-Sandino, A., Luissint, A. C., Kusters, D. H., Narayanan, V., Flemming, S., Garcia-Hernandez, V., ... & Nusrat, A. (2021). Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2. Molecular biology of the cell, 32(8), 753-768.

Ahram, M., Abdullah, M. S., Mustafa, S. A., Alsafadi, D. B., & Battah, A. H. (2021). Androgen downregulates desmocollin‐2 in association with induction of mesenchymal transition of breast MDA‐MB‐453 cancer cells. Cytoskeleton, 78(8), 391-399.

Flemming, S., Luissint, A. C., Kusters, D. H., Raya-Sandino, A., Fan, S., Zhou, D. W., ... & Nusrat, A. (2020). Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration. Molecular biology of the cell, 31(6), 407-418.

Chen, D. Q., Shen, X. B., Zhang, S. H., Ye, G. Y., & Xu, S. H. (2019). Malignant Arrhythmia with Variants of Desmocollin-2 and Desmoplakin Genes A Case Report. International Heart Journal, 18-681.

Brodehl, A., Stanasiuk, C., Anselmetti, D., Gummert, J., & Milting, H. (2019). Incorporation of desmocollin‐2 into the plasma membrane requires N‐glycosylation at multiple sites. FEBS Open bio, 9(5), 996-1007.

Hermida, A., Fressart, V., Hidden‐Lucet, F., Donal, E., Probst, V., Deharo, J. C., ... & Gandjbakhch, E. (2019). High risk of heart failure associated with desmoglein‐2 mutations compared to plakophilin‐2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia. European journal of heart failure, 21(6), 792-800.

Gross, A., Pack, L. A., Schacht, G. M., Kant, S., Ungewiss, H., Meir, M., ... & Strnad, P. (2018). Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury. Mucosal immunology, 11(6), 1630-1639.

Mazurek, S. R., Calway, T., Harmon, C., Farrell, P., & Kim, G. H. (2017). MicroRNA-130a regulation of desmocollin 2 in a novel model of arrhythmogenic cardiomyopathy. MicroRNA, 6(2), 143-150.

Brodehl, A., Belke, D. D., Garnett, L., Martens, K., Abdelfatah, N., Rodriguez, M., ... & Gerull, B. (2017). Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling. PLoS One, 12(3), e0174019.

Hütz, K., Zeiler, J., Sachs, L., Ormanns, S., & Spindler, V. (2017). Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells. Molecular Carcinogenesis, 56(8), 1884-1895.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used DSC2 Matched Antibody Pair (352)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry