Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-DSC2 Recombinant Antibody (023) (V2LY-0425-LY951)


See all DSC2 antibodies
Online Inquiry

Summary

Host Animal
Rabbit
Specificity
Human
Clone
023
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human DSC2 Protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Desmocollin 2
Entrez Gene ID
291760
UniProt ID
D3ZJR7
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Biological Process
Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cardiac muscle cell-cardiac muscle cell adhesion Source: UniProtKB
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Topology
Extracellular: 136-694
Helical: 695-715
Cytoplasmic: 716-901
More Infomation

Raya-Sandino, A., Luissint, A. C., Kusters, D. H., Narayanan, V., Flemming, S., Garcia-Hernandez, V., ... & Nusrat, A. (2021). Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2. Molecular biology of the cell, 32(8), 753-768.

Ahram, M., Abdullah, M. S., Mustafa, S. A., Alsafadi, D. B., & Battah, A. H. (2021). Androgen downregulates desmocollin‐2 in association with induction of mesenchymal transition of breast MDA‐MB‐453 cancer cells. Cytoskeleton, 78(8), 391-399.

Flemming, S., Luissint, A. C., Kusters, D. H., Raya-Sandino, A., Fan, S., Zhou, D. W., ... & Nusrat, A. (2020). Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration. Molecular biology of the cell, 31(6), 407-418.

Chen, D. Q., Shen, X. B., Zhang, S. H., Ye, G. Y., & Xu, S. H. (2019). Malignant Arrhythmia with Variants of Desmocollin-2 and Desmoplakin Genes A Case Report. International Heart Journal, 18-681.

Brodehl, A., Stanasiuk, C., Anselmetti, D., Gummert, J., & Milting, H. (2019). Incorporation of desmocollin‐2 into the plasma membrane requires N‐glycosylation at multiple sites. FEBS Open bio, 9(5), 996-1007.

Hermida, A., Fressart, V., Hidden‐Lucet, F., Donal, E., Probst, V., Deharo, J. C., ... & Gandjbakhch, E. (2019). High risk of heart failure associated with desmoglein‐2 mutations compared to plakophilin‐2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia. European journal of heart failure, 21(6), 792-800.

Gross, A., Pack, L. A., Schacht, G. M., Kant, S., Ungewiss, H., Meir, M., ... & Strnad, P. (2018). Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury. Mucosal immunology, 11(6), 1630-1639.

Mazurek, S. R., Calway, T., Harmon, C., Farrell, P., & Kim, G. H. (2017). MicroRNA-130a regulation of desmocollin 2 in a novel model of arrhythmogenic cardiomyopathy. MicroRNA, 6(2), 143-150.

Brodehl, A., Belke, D. D., Garnett, L., Martens, K., Abdelfatah, N., Rodriguez, M., ... & Gerull, B. (2017). Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling. PLoS One, 12(3), e0174019.

Hütz, K., Zeiler, J., Sachs, L., Ormanns, S., & Spindler, V. (2017). Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells. Molecular Carcinogenesis, 56(8), 1884-1895.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-DSC2 Recombinant Antibody (023)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry