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DGKA Matched Antibody Pair (337) (APMAB-337LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-DGKA polyclonal antibody, 100 ug
Detection Antibody
Anti-DGKA Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
Alternative Names
Diacylglycerol Kinase Alpha; Diacylglycerol Kinase, Alpha 80kDa; 80 KDa Diacylglycerol Kinase; Diglyceride Kinase Alpha; DAG Kinase Alpha; EC 2.7.1.107;
Entrez Gene ID
1606
UniProt ID
P23743
More Infomation

Okada, N., Sugiyama, K., Shichi, S., Shirai, Y., Goto, K., Sakane, F., ... & Taketomi, A. (2022). Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade. Cancer Immunology, Immunotherapy, 71(4), 889-903.

Li, J., Shen, Y., Chen, Y., Zhang, Z., Ma, S., Wan, Q., ... & Yang, J. (2021). Structure of membrane diacylglycerol kinase in lipid bilayers. Communications biology, 4(1), 1-13.

Liu, C. S., Toth, R., Bakr, A., Goyal, A., Islam, M. S., Breuer, K., ... & Popanda, O. (2021). Epigenetic modulation of radiation-induced diacylglycerol kinase alpha expression prevents pro-fibrotic fibroblast response. Cancers, 13(10), 2455.

Liu, C. S., Schmezer, P., & Popanda, O. (2020). Diacylglycerol kinase alpha in radiation-induced fibrosis: Potential as a predictive marker or therapeutic target. Frontiers in Oncology, 10, 737.

Pan, Y., Deng, W., Xie, J., Zhang, S., Wan, E. C., Li, L., ... & Zhong, X. P. (2020). Graded diacylglycerol kinases α and ζ activities ensure mucosal‐associated invariant T‐cell development in mice. European journal of immunology, 50(2), 192-204.

Chen, J., Zhang, W., Wang, Y., Zhao, D., Wu, M., Fan, J., ... & Zhan, Q. (2019). The diacylglycerol kinase α (DGKα)/Akt/NF-κB feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner. Oncogene, 38(14), 2533-2550.

Olmez, I., Love, S., Xiao, A., Manigat, L., Randolph, P., McKenna, B. D., ... & Purow, B. (2018). Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha. Neuro-oncology, 20(2), 192-202.

Kelly, E., Sharma, D., Wilkinson, C. J., & Williams, R. S. (2018). Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum. Disease models & mechanisms, 11(9), dmm035600.

Valinciute, G., Weigel, C., Veldwijk, M. R., Oakes, C. C., Herskind, C., Wenz, F., ... & Popanda, O. (2017). BET-bromodomain inhibitors modulate epigenetic patterns at the diacylglycerol kinase alpha enhancer associated with radiation-induced fibrosis. Radiotherapy and Oncology, 125(1), 168-174.

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For research use only. Not intended for any clinical use.

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