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DDC Matched Antibody Pair (330) (APMAB-330LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-DDC polyclonal antibody, 100 ug
Detection Antibody
Anti-DDC Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
Alternative Names
Dopa Decarboxylase; DOPA Decarboxylase; EC 4.1.1.28; AADC; Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase); Aromatic L-Amino Acid Decarboxylase; Aromatic-L-Amino-Acid Decarboxylase; EC 4.1.1;
Entrez Gene ID
1644
UniProt ID
P20711
More Infomation

Mpekoulis, G., Frakolaki, E., Taka, S., Ioannidis, A., Vassiliou, A. G., Kalliampakou, K. I., ... & Vassilaki, N. (2021). Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform. PloS one, 16(6), e0253458.

Papatsirou, M., Adamopoulos, P. G., Artemaki, P. I., Georganti, V. P., Scorilas, A., Vassilacopoulou, D., & Kontos, C. K. (2021). Next-generation sequencing reveals alternative L-DOPA decarboxylase (DDC) splice variants bearing novel exons, in human hepatocellular and lung cancer cells. Gene, 768, 145262.

Chalatsa, I., Arvanitis, N., Arvanitis, D., Tsakou, A. C., Kalantzis, E. D., Vassiliou, A. G., ... & Vassilacopoulou, D. (2020). Human L-Dopa decarboxylase interaction with annexin V and expression during apoptosis. Biochimie, 177, 78-86.

Artemaki, P. I., Papatsirou, M., Boti, M. A., Adamopoulos, P. G., Christodoulou, S., Vassilacopoulou, D., ... & Kontos, C. K. (2020). Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression. International journal of molecular sciences, 21(22), 8568.

Stefi, A. L., Vassilacopoulou, D., & Christodoulakis, N. S. (2019). Environmentally stressed summer leaves of the seasonally dimorphic Phlomis fruticosa and the relief through the L-Dopa decarboxylase (DDC). Flora, 251, 11-19.

Frakolaki, E., Kalliampakou, K. I., Kaimou, P., Moraiti, M., Kolaitis, N., Boleti, H., ... & Vassilaki, N. (2019). Emerging role of l-Dopa decarboxylase in flaviviridae virus infections. Cells, 8(8), 837.

Vassiliou, A. G., Siaterli, M. Z., Frakolaki, E., Gkogkosi, P., Paspaltsis, I., Sklaviadis, T., ... & Vassilaki, N. (2019). L-Dopa decarboxylase interaction with the major signaling regulator ΡΙ3Κ in tissues and cells of neural and peripheral origin. Biochimie, 160, 76-87.

Adamopoulos, P. G., Tsiakanikas, P., Kontos, C. K., Panagiotou, A., Vassilacopoulou, D., & Scorilas, A. (2019). Identification of novel alternative splice variants of the human L-DOPA decarboxylase (DDC) gene in human cancer cells, using high-throughput sequencing approaches. Gene, 719, 144075.

Wang, K., Ren, Q., Shen, X. L., Li, B., Du, J., Yu, X. D., & Du, Z. Q. (2019). Molecular characterization and expression analysis of dopa decarboxylase involved in the antibacterial innate immunity of the freshwater crayfish, Procambarus clarkii. Fish & Shellfish Immunology, 91, 19-28.

Kow, R. L., Sikkema, C., Wheeler, J. M., Wilkinson, C. W., & Kraemer, B. C. (2018). DOPA decarboxylase modulates tau toxicity. Biological psychiatry, 83(5), 438-446.

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For research use only. Not intended for any clinical use.

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