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Mouse Anti-DDC Recombinant Antibody (CBYC-A948) (CBMAB-A4376-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-A948
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human DDC protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dopa Decarboxylase
Introduction
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (
Entrez Gene ID
1644
UniProt ID
P20711
Alternative Names
Dopa Decarboxylase; DOPA Decarboxylase; EC 4.1.1.28; AADC; Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase); Aromatic L-Amino Acid Decarboxylase; Aromatic-L-Amino-Acid Decarboxylase; EC 4.1.1;
Function
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Biological Process
Aminergic neurotransmitter loading into synaptic vesicle Source: Ensembl
Catecholamine biosynthetic process Source: Reactome
Catecholamine metabolic process Source: GO_Central
Cellular amino acid metabolic process Source: InterPro
Cellular response to alkaloid Source: Ensembl
Cellular response to drug Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Circadian rhythm Source: Ensembl
Dopamine biosynthetic process Source: UniProtKB-UniPathway
Indolalkylamine biosynthetic process Source: Reactome
Isoquinoline alkaloid metabolic process Source: Ensembl
Multicellular organism aging Source: Ensembl
Phytoalexin metabolic process Source: Ensembl
Response to pyrethroid Source: Ensembl
Serotonin biosynthetic process Source: GO_Central
Cellular Location
Cytosol; Extracellular exosome; Axon; Cytoplasm; Neuronal cell body; Synaptic vesicle
Involvement in disease
Aromatic L-amino-acid decarboxylase deficiency (AADCD):
An inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
More Infomation

Mpekoulis, G., Frakolaki, E., Taka, S., Ioannidis, A., Vassiliou, A. G., Kalliampakou, K. I., ... & Vassilaki, N. (2021). Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform. PloS one, 16(6), e0253458.

Papatsirou, M., Adamopoulos, P. G., Artemaki, P. I., Georganti, V. P., Scorilas, A., Vassilacopoulou, D., & Kontos, C. K. (2021). Next-generation sequencing reveals alternative L-DOPA decarboxylase (DDC) splice variants bearing novel exons, in human hepatocellular and lung cancer cells. Gene, 768, 145262.

Chalatsa, I., Arvanitis, N., Arvanitis, D., Tsakou, A. C., Kalantzis, E. D., Vassiliou, A. G., ... & Vassilacopoulou, D. (2020). Human L-Dopa decarboxylase interaction with annexin V and expression during apoptosis. Biochimie, 177, 78-86.

Artemaki, P. I., Papatsirou, M., Boti, M. A., Adamopoulos, P. G., Christodoulou, S., Vassilacopoulou, D., ... & Kontos, C. K. (2020). Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression. International journal of molecular sciences, 21(22), 8568.

Stefi, A. L., Vassilacopoulou, D., & Christodoulakis, N. S. (2019). Environmentally stressed summer leaves of the seasonally dimorphic Phlomis fruticosa and the relief through the L-Dopa decarboxylase (DDC). Flora, 251, 11-19.

Frakolaki, E., Kalliampakou, K. I., Kaimou, P., Moraiti, M., Kolaitis, N., Boleti, H., ... & Vassilaki, N. (2019). Emerging role of l-Dopa decarboxylase in flaviviridae virus infections. Cells, 8(8), 837.

Vassiliou, A. G., Siaterli, M. Z., Frakolaki, E., Gkogkosi, P., Paspaltsis, I., Sklaviadis, T., ... & Vassilaki, N. (2019). L-Dopa decarboxylase interaction with the major signaling regulator ΡΙ3Κ in tissues and cells of neural and peripheral origin. Biochimie, 160, 76-87.

Adamopoulos, P. G., Tsiakanikas, P., Kontos, C. K., Panagiotou, A., Vassilacopoulou, D., & Scorilas, A. (2019). Identification of novel alternative splice variants of the human L-DOPA decarboxylase (DDC) gene in human cancer cells, using high-throughput sequencing approaches. Gene, 719, 144075.

Wang, K., Ren, Q., Shen, X. L., Li, B., Du, J., Yu, X. D., & Du, Z. Q. (2019). Molecular characterization and expression analysis of dopa decarboxylase involved in the antibacterial innate immunity of the freshwater crayfish, Procambarus clarkii. Fish & Shellfish Immunology, 91, 19-28.

Kow, R. L., Sikkema, C., Wheeler, J. M., Wilkinson, C. W., & Kraemer, B. C. (2018). DOPA decarboxylase modulates tau toxicity. Biological psychiatry, 83(5), 438-446.

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For research use only. Not intended for any clinical use.

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