CBL Matched Antibody Pair (189) (APMAB-189LY)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-CBL polyclonal antibody, 100 ug

Detection Antibody

Anti-CBL Mouse monoclonal, IgG1 antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]

Alternative Names

Cbl Proto-Oncogene; Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence; Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase; Casitas B-Lineage Lymphoma Proto-Oncogene; RING-Type E3 Ubiquitin Transferase CBL; Signal Transduction Protein CBL; RING Finger Protein 55; Proto-Oncogene C-Cbl; Oncogene CBL2; RNF55;

Entrez Gene ID

867

UniProt ID

P22681

More Infomation

References

Mamoor, S. (2020). Casitas B-lineage Lymphoma (CBL) is differentially expressed in the tumors of breast cancer patients treated with trastuzumab.

Kumaradevan, S., Lee, S. Y., Richards, S., Lyle, C., Zhao, Q., Tapan, U., ... & Chitalia, V. C. (2018). C-cbl expression correlates with human colorectal cancer survival and its Wnt/β-catenin suppressor function is regulated by Tyr371 phosphorylation. The American journal of pathology, 188(8), 1921-1933.

Jeong, J. S., Kim, H. Y., Shin, B. S., Lee, A. R., Yoon, J. H., Hahm, T. S., & Lee, J. E. (2018). Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy. BMC anesthesiology, 18(1), 1-9.

Lee, G. W., Park, J. B., Park, S. Y., Seo, J., Shin, S. H., Park, J. W., ... & Chun, Y. S. (2018). The E3 ligase C-CBL inhibits cancer cell migration by neddylating the proto-oncogene c-Src. Oncogene, 37(41), 5552-5568.

Rojas‐Ríos, P., Chartier, A., Pierson, S., & Simonelig, M. (2017). Aubergine and pi RNA s promote germline stem cell self‐renewal by repressing the proto‐oncogene Cbl. The EMBO journal, 36(21), 3194-3211.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

CBL Matched Antibody Pair (188)

Antibody Pairs

CBL Matched Antibody Pair (188)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Second antibody and isotype control

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