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CARD8 Matched Antibody Pair (182) (APMAB-182LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CARD8 polyclonal antibody, 100 ug
Detection Antibody
Anti-CARD8 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Alternative Names
Caspase Recruitment Domain Family Member 8; Tumor Up-Regulated CARD-Containing Antagonist Of CASP9; Apoptotic Protein NDPP1; CARDINAL; DACAR; NDPP1; TUCAN; Tumor Up-Regulated CARD-Containing Antagonist Of Caspase Nine;
Entrez Gene ID
22900
UniProt ID
Q9Y2G2
More Infomation

Hollingsworth, L. R., David, L., Li, Y., Griswold, A. R., Ruan, J., Sharif, H., ... & Wu, H. (2021). Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nature communications, 12(1), 1-13.

Wang, Q., Gao, H., Clark, K. M., Mugisha, C. S., Davis, K., Tang, J. P., ... & Shan, L. (2021). CARD8 is an inflammasome sensor for HIV-1 protease activity. Science, 371(6535).

Gong, Q., Robinson, K., Xu, C., Huynh, P. T., Chong, K. H. C., Tan, E. Y. J., ... & Wu, B. (2021). Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8. Nature communications, 12(1), 1-15.

Mahendra, J., Rao, A. N., Mahendra, L., Fageeh, H. N., Fageeh, H. I., Balaji, T. M., ... & Patil, S. (2021). Genetic Polymorphisms of NLRP3 (rs4612666) and CARD8 (rs2043211) in Periodontitis and Cardiovascular Diseases. Biology, 10(7), 592.

Johnson, D. C., Okondo, M. C., Orth, E. L., Rao, S. D., Huang, H. C., Ball, D. P., & Bachovchin, D. A. (2020). DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes. Cell death & disease, 11(8), 1-10.

Linder, A., Bauernfried, S., Cheng, Y., Albanese, M., Jung, C., Keppler, O. T., & Hornung, V. (2020). CARD8 inflammasome activation triggers pyroptosis in human T cells. The EMBO journal, 39(19), e105071.

Taabazuing, C. Y., Griswold, A. R., & Bachovchin, D. A. (2020). The NLRP1 and CARD8 inflammasomes. Immunological Reviews, 297(1), 13-25.

Chui, A. J., Griswold, A. R., Taabazuing, C. Y., Orth, E. L., Gai, K., Rao, S. D., ... & Bachovchin, D. A. (2020). Activation of the CARD8 inflammasome requires a disordered region. Cell reports, 33(2), 108264.

Tsetsos, F., Roumeliotis, A., Tsekmekidou, X., Alexouda, S., Roumeliotis, S., Theodoridis, M., ... & Georgitsi, M. (2020). Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus. Diabetes and Vascular Disease Research, 17(6), 1479164120970892.

Griswold, A. R., Ball, D. P., Bhattacharjee, A., Chui, A. J., Rao, S. D., Taabazuing, C. Y., & Bachovchin, D. A. (2019). DPP9’s enzymatic activity and not its binding to CARD8 inhibits inflammasome activation. ACS chemical biology, 14(11), 2424-2429.

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For research use only. Not intended for any clinical use.

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