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BAG1 Matched Antibody Pair (123) (APMAB-123LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-BAG1 monoclonal, IgG2a antibody, 100 ug
Detection Antibody
Anti-BAG1 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
Alternative Names
BCL2 Associated Athanogene 1; BAG-1; HAP; Glucocortoid Receptor-Associated Protein RAP46; BAG Family Molecular Chaperone Regulator 1; Bcl-2 Associating Athanogene-1 Protein; Receptor-Associated Protein, 46-KD;
Entrez Gene ID
573
UniProt ID
Q99933
More Infomation

Turk, M., Tatli, O., Alkan, H. F., Ozfiliz Kilbas, P., Alkurt, G., & Dinler Doganay, G. (2021). Co-Chaperone Bag-1 Plays a Role in the Autophagy-Dependent Cell Survival through Beclin 1 Interaction. Molecules, 26(4), 854.

Can, N. D., Basturk, E., Kizilboga, T., Akcay, I. M., Dingiloglu, B., Tatli, O., ... & Dinler Doganay, G. (2021). Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation. PloS one, 16(8), e0256640.

Luo, S., Hou, Y., Zhang, Y., Feng, L., Hunter, R. G., Yuan, P., ... & Du, J. (2021). Bag‐1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience. Journal of Neurochemistry, 158(2), 358-372.

Nguyen, P., Hess, K., Smulders, L., Le, D., Briseno, C., Chavez, C. M., & Nikolaidis, N. (2020). Origin and evolution of the human Bcl2-associated athanogene-1 (BAG-1). International journal of molecular sciences, 21(24), 9701.

Song, Y. K., Li, Z., Wang, Y., Qu, Y., Li, Q. S., Man, X. Y., ... & Hu, D. (2020). Inhibition of BAG‐1 induced SH‐SY5Y cell apoptosis without affecting Hsp70 expression. Journal of cellular biochemistry, 121(2), 1728-1735.

Kirschke, E., Roe-Zurz, Z., Noddings, C., & Agard, D. (2020). The interplay between Bag-1, Hsp70, and Hsp90 reveals that inhibiting Hsp70 rebinding is essential for Glucocorticoid Receptor activity. bioRxiv.

Papadakis, E. S., Reeves, T., Robson, N. H., Maishman, T., Packham, G., & Cutress, R. I. (2017). BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses. British journal of cancer, 116(12), 1585-1594.

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For research use only. Not intended for any clinical use.

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