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ATF4 Matched Antibody Pair (114) (APMAB-114LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-ATF4 polyclonal antibody, 100 ug
Detection Antibody
Anti-ATF4 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
Alternative Names
Activating Transcription Factor 4; Tax-Responsive Enhancer Element-Binding Protein 67; Cyclic AMP-Responsive Element-Binding Protein 2; CAMP-Responsive Element-Binding Protein 2; CAMP-Dependent Transcription Factor ATF-4; Tax-Responsive Enhancer Element B67; DNA-Binding Protein TAXREB67; TAXREB67;
Entrez Gene ID
468
UniProt ID
P18848
More Infomation

Demmings, M. D., Tennyson, E. C., Petroff, G. N., Tarnowski-Garner, H. E., & Cregan, S. P. (2021). Activating transcription factor-4 promotes neuronal death induced by Parkinson’s disease neurotoxins and α-synuclein aggregates. Cell Death & Differentiation, 28(5), 1627-1643.

Lorenz, N. I., Sittig, A. C., Urban, H., Luger, A. L., Engel, A. L., Münch, C., ... & Ronellenfitsch, M. W. (2021). Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide. Scientific reports, 11(1), 1-11.

Ebert, S. M., Bullard, S. A., Basisty, N., Marcotte, G. R., Skopec, Z. P., Dierdorff, J. M., ... & Adams, C. M. (2020). Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ. Journal of Biological Chemistry, 295(9), 2787-2803.

Liu, T. H., Tao, W. C., Liang, Q. E., Tu, W. Q., Xiao, Y., & Chen, L. G. (2020). Gut microbiota-related evidence provides new insights into the association between activating transcription factor 4 and development of salt-induced hypertension in mice. Frontiers in cell and developmental biology, 8, 1283.

Mukherjee, D., Bercz, L. S., Torok, M. A., & Mace, T. A. (2020). Regulation of cellular immunity by activating transcription factor 4. Immunology Letters.

Wang, X., Han, Y., Hu, G., Guo, J., & Chen, H. (2020). Endoplasmic reticulum stress induces miR-706, a pro-cell death microRNA, in a protein kinase RNA-like ER kinase (PERK) and activating transcription factor 4 (ATF4) dependent manner. Cell Journal (Yakhteh), 22(3), 394.

Ou, L., Lan, Y., Feng, Z., Feng, L., Yang, J., Liu, Y., ... & Guo, R. (2019). Functionalization of SF/HAP Scaffold with GO-PEI-miRNA inhibitor complexes to enhance bone regeneration through activating transcription factor 4. Theranostics, 9(15), 4525.

Liu, J., Amar, F., Corona, C., So, R. W., Andrews, S. J., Nagy, P. L., ... & Greene, L. A. (2018). Brain-derived neurotrophic factor elevates activating transcription factor 4 (ATF4) in neurons and promotes ATF4-dependent induction of Sesn2. Frontiers in molecular neuroscience, 11, 62.

Corona, C., Pasini, S., Liu, J., Amar, F., Greene, L. A., & Shelanski, M. L. (2018). Activating transcription factor 4 (ATF4) regulates neuronal activity by controlling GABABR trafficking. Journal of Neuroscience, 38(27), 6102-6113.

Lai, D. W., Lin, K. H., Sheu, W. H. H., Lee, M. R., Chen, C. Y., Lee, W. J., ... & Sheu, M. L. (2017). TPL2 (therapeutic targeting tumor progression locus-2)/ATF4 (activating transcription factor-4)/SDF1α (chemokine stromal cell-derived factor-α) axis suppresses diabetic retinopathy. Circulation research, 121(6), e37-e52.

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For research use only. Not intended for any clinical use.

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