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ATF1 Matched Antibody Pair (112) (APMAB-112LY)


See all ATF1 antibodies
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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-ATF1 polyclonal antibody, 100 ug
Detection Antibody
Anti-ATF1 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
Alternative Names
Activating Transcription Factor 1; CAMP-Dependent Transcription Factor ATF-1; Cyclic AMP-Dependent Transcription Factor ATF-1; Protein TREB36; FUS/ATF-1; EWS-ATF1; TREB36;
Entrez Gene ID
466
UniProt ID
P18846
More Infomation

Tabara, M., Shiraishi, K., Takii, R., Fujimoto, M., Nakai, A., & Matsuyama, H. (2021). Testicular localization of activating transcription factor 1 and its potential function during spermatogenesis. Biology of Reproduction.

Seneviratne, A., Han, Y., Wong, E., Walter, E. R., Jiang, L., Cave, L., ... & Boyle, J. J. (2020). Hematoma resolution in vivo is directed by activating transcription factor 1. Circulation research, 127(7), 928-944.

Ge, Y., Cave, L., Seneviratne, A., Carling, D., Mason, J. C., Haskard, D., & Boyle, J. J. (2020). Switching macrophage gene expression from inflammation-resolution to hemorrhage-resolution by redirection of activating transcription factor 1 (ATF1) binding by SMARCA4, BACH1 and histone H3K9 acetylation. Atherosclerosis, 315, e2.

Wu, L., Guo, Y., Cai, S., Kuang, L., Shen, Q., Wu, D., & Zhang, G. (2020). The zinc finger transcription factor ATF1 regulates aluminum tolerance in barley. Journal of Experimental Botany, 71(20), 6512-6523.

Cui, J., Yin, Z., Liu, G., Chen, X., Gao, X., Lu, H., ... & Lin, D. (2019). Activating transcription factor 1 promoted migration and invasion in lung cancer cells through regulating EGFR and MMP‐2. Molecular carcinogenesis, 58(10), 1919-1924.

Boyle, J., Seneviratne, A., Han, Y., Jiang, L., Walter, E., Cave, L., ... & Haskard, D. O. (2019). Vertebrate Hematoma Resolution Is Directed By Activating Transcription Factor 1 (Atf1) And Adenosine-Monophosphate-Activated-Protein-Kinase (Ampk). Atherosclerosis, 287, e246.

Boyle, J., Seneviratne, A., Tsao, A., Shaikh, A., Carling, D., Haskard, D. O., & Cave, L. (2019). Smarca4 Redirects Binding Of Macrophage Activating Transcription Factor 1 (Atf1) From Genes For Inflammation Resolution To Genes For Erythrocyte Resolution. Atherosclerosis, 287, e78.

Hao, Q., Zhao, X., Zhang, Y., Dong, Z., Hu, T., & Chen, P. (2017). Targeting overexpressed activating transcription factor 1 (ATF1) inhibits proliferation and migration and enhances sensitivity to paclitaxel in esophageal cancer cells. Medical science monitor basic research, 23, 304.

Shi, Y., Wang, W., Yang, B., & Tian, H. (2017). ATF1 and RAS in exosomes are potential clinical diagnostic markers for cervical cancer. Cell biochemistry and function, 35(7), 477-483.

Salat-Canela, C., Paulo, E., Sánchez-Mir, L., Carmona, M., Ayté, J., Oliva, B., & Hidalgo, E. (2017). Deciphering the role of the signal-and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation. Journal of Biological Chemistry, 292(33), 13635-13644.

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For research use only. Not intended for any clinical use.

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