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Mouse Anti-ZYX Monoclonal Antibody (ZOL301) (CBMAB-1727-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
ZOL301
Antibody Isotype
IgG2a
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
Conjugated to KLH by an N-terminal Cysteine residue linker, corresponding to amino acids 134-150 of Human Zyxin
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Zyxin
Introduction
Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding.
Entrez Gene ID
Human7791
Mouse22793
Rat114636
UniProt ID
HumanQ15942
MouseQ62523
RatD4A7U1
Alternative Names
ESP-2; HED-2
Function
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cell-matrix adhesion1 PublicationIC:UniProtKB
Cellular response to interferon-gammaIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of inflammatory responseIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Nucleus
Cell junction, focal adhesion
Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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