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Mouse Anti-ZNFX1 Recombinant Antibody (1E6) (CBMAB-0693-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E6
Antibody Isotype
IgG2c
Application
IP, MA

Basic Information

Immunogen
Protein Domain
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ZNFX1
Entrez Gene ID
57169
UniProt ID
Q9P2E3
Alternative Names
FLJ11277; KIAA1404
Function
RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses (PubMed:33872655).
Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (By similarity).
Also required for immunity against some bacteria, such as mycobacteria (PubMed:33876776).
Biological Process
Biological Process activation of innate immune response Source:UniProtKB
Biological Process defense response to bacterium Source:UniProtKB1 Publication
Biological Process defense response to virus Source:UniProtKB1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of viral genome replication Source:UniProtKB
Biological Process RNA-mediated heterochromatin formation Source:GO_Central1 Publication
Cellular Location
Mitochondrion outer membrane
Cytoplasm, Stress granule
Involvement in disease
Immunodeficiency 91 and hyperinflammation (IMD91):
An autosomal recessive disorder characterized by immunodeficiency, recurrent infections, and hyperinflammation with systemic involvement. Most patients eventually develop hepatic or renal failure, may have compromised neurologic function, lymphadenopathy or hepatosplenomegaly. Early death often occurs due to multiorgan failure.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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