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Mouse Anti-ZNF746 Recombinant Antibody (1B7) (CBMAB-0744-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B7
Antibody Isotype
IgG2a
Application
IP, MA, WB

Basic Information

Immunogen
Full length
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
zinc finger protein 746
Introduction
Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
Entrez Gene ID
155061
UniProt ID
Q6NUN9
Alternative Names
FLJ31413
Function
Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
Biological Process
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of neuron death Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:ParkinsonsUK-UCL1 Publication
Biological Process protein heterooligomerization Source:UniProtKB1 Publication
Biological Process protein homooligomerization Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
Note: Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.
PTM
Ubiquitinated by PRKN. 'Lys-48'-linked polyubiquitination by PRKN leads to degradation by the proteasome and may play a key role in regulation of neuron death.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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