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Mouse anti-ZNF346 Recombinant Antibody (2D10) (CBMAB-1319-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2D10
Antibody Isotype
IgG1, Κ
Application
ELISA, WB

Basic Information

Immunogen
ZNF346 partial recombinant protein with GST tag. Immunogen sequence: NQCCPICNMT FSSPVVAQSH YLGKTHAKNL KLKQQSTKVE ALHQNREMID PDKFCSLCHA TFNDPVMAQQ HYVGKKHRKQ ETKLKLMARY GRLADPAVTD
Specificity
Human
Antibody Isotype
IgG1, Κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Zinc Finger Protein 346
Introduction
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins.
Entrez Gene ID
23567
UniProt ID
Q9UL40
Alternative Names
JAZ; Zfp346
Function
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053).
May bind to specific miRNA hairpins (PubMed:28431233).
Cellular Location
Nucleus, nucleolus
Cytoplasm
Note: Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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