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Mouse Anti-ZNF274 Recombinant Antibody (4C12) (CBMAB-Z0461-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4C12
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
ZNF274 (AA420-530) partial recombinant protein with GST tag. Immunogen sequence: QKIDNPESQA NSGALDTNQV LLHKIPPRKR LRKRDSQVKS MKHNSRVKIH QKSCERQKAK EGNGCRKTFS RSTKQITFIR IHKGSQVCRC SECGKIFRNP RYFSVHKKIH T
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
zinc finger protein 274
Introduction
ZNF274 (Zinc Finger Protein 274) is a Protein Coding gene. Diseases associated with ZNF274 include Frasier Syndrome. Among its related pathways are Gene Expression and Development HGF signaling pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ZNF483.
Entrez Gene ID
10782
UniProt ID
Q96GC6
Alternative Names
ZF2; HFB101; ZSCAN51; ZKSCAN19
Function
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).
Biological Process
Biological Process negative regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process regulation of DNA-templated transcription Source:ProtInc1 Publication
Biological Process regulation of histone H3-K9 trimethylation Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus, nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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