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Mouse Anti-ZNF268 Recombinant Antibody (3B4) (CBMAB-Z0459-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ZNF268 (AA1-90) partial recombinant protein with GST tag. Immunogen sequence: MATRVRTASI WVPPLQERNS SWDRIRKLQG QESILGQGTP GLQPLPGTPR QKQKSRRIEK VLEWLFISQE QPKITKSWGP LSFMDVFVDF
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
zinc finger protein 268
Introduction
ZNF268 (Zinc Finger Protein 268) is a Protein Coding gene. Diseases associated with ZNF268 include Cervical Cancer and Ovarian Cancer. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF850.
Entrez Gene ID
10795
UniProt ID
Q14587
Alternative Names
HZF3
Function
Isoform 1
Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.
Isoform 2
Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
Biological Process
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process cellular response to tumor necrosis factor Source:UniProtKB
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:UniProtKB2 Publications
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cell differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:UniProtKB
Biological Process positive regulation of protein catabolic process Source:UniProtKB
Biological Process positive regulation of protein homodimerization activity Source:UniProtKB
Biological Process positive regulation of protein phosphorylation Source:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process regulation of protein heterodimerization activity Source:UniProtKB
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Isoform 1
Nucleus
Isoform 2
Nucleus
Cytoplasm
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For research use only. Not intended for any clinical use.

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