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Mouse Anti-ZNF263 Recombinant Antibody (2A1) (CBMAB-A10142-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2A1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ZNF263 (NP_005732, 201 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Zinc Finger Protein 263
Entrez Gene ID
10127
UniProt ID
O14978
Alternative Names
FPM315; ZKSCAN12
Function
Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553).
Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553).
Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030).
Biological Process
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:ProtInc1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
PTM
Ubiquitinated, leading to proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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