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Mouse Anti-ZNF207 Recombinant Antibody (1A6) (CBMAB-0881-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A6
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Protein Domain
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
zinc finger protein 207
Introduction
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome.
Entrez Gene ID
7756
UniProt ID
O43670
Function
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440).
ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440).
Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187).
Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186).
According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
Biological Process
Biological Process attachment of spindle microtubules to kinetochore Source:UniProtKB2 Publications
Biological Process cell division Source:UniProtKB-KW
Biological Process microtubule bundle formation Source:UniProtKB
Biological Process microtubule polymerization Source:UniProtKB
Biological Process mitotic sister chromatid segregation Source:UniProtKB2 Publications
Biological Process mitotic spindle assembly Source:UniProtKB1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:UniProtKB2 Publications
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process regulation of chromosome segregation Source:UniProtKB2 Publications
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Cytoplasm, cytoskeleton, spindle
Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding.
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For research use only. Not intended for any clinical use.

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