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Mouse Anti-ZIC2 Recombinant Antibody (4A7) (CBMAB-Z0268-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4A7
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ZIC2 (AA151-216) full length recombinant protein with GST tag. Immunogen sequence: SDAQGHLLFP GLPEQHGPHG SQNVLNGQMR LGLPGEVFGR SEQYRQ VASP RTDPY
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
ZIC2
Introduction
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones.
Entrez Gene ID
7546
UniProt ID
O95409
Alternative Names
HPE5
Function
Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Biological Process
Biological Process brain development Source:ProtInc1 Publication
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process central nervous system development Source:GO_Central1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process visual perception Source:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity).
Involvement in disease
Holoprosencephaly 5 (HPE5):
A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
PTM
Phosphorylated.
Ubiquitinated by RNF180, leading to its degradation.
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For research use only. Not intended for any clinical use.

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