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Mouse Anti-ZGPAT Recombinant Antibody (CBWJZ-087) (CBMAB-Z0251-WJ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBWJZ-087
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
zinc finger CCCH-type and G-patch domain containing
Introduction
ZGPAT (Zinc Finger CCCH-Type And G-Patch Domain Containing) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding.
Entrez Gene ID
Human84619
Mouse229007
Rat296478
UniProt ID
HumanQ8N5A5
MouseQ8VDM1
RatQ5PPF5
Alternative Names
ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847
Function
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
Isoform 4
Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.
Biological Process
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of epidermal growth factor-activated receptor activity Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
Isoform 4
Nucleus
PTM
Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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