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Mouse Anti-ZFYVE20 Monoclonal Antibody (1E2) (CBMAB-0385-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E2
Antibody Isotype
IgG1
Application
IP, MA, WB

Basic Information

Immunogen
Recombinant peptide (aa 741-784)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ZFYVE20
Introduction
This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).
Entrez Gene ID
64145
UniProt ID
Q9H1K0
Alternative Names
Rabenosyn-5
Function
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713).
Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388).
Biological Process
Biological Process early endosome to Golgi transport Source:UniProtKB1 Publication
Biological Process endosomal transport Source:UniProtKB1 Publication
Biological Process Golgi to lysosome transport Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process regulation of Golgi organization Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Early endosome membrane
Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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