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Mouse Anti-ZFYVE16 Recombinant Antibody (2E2) (CBMAB-A10034-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E2
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
ZFYVE16 (NP_055548, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Zinc Finger FYVE-Type Containing 16
Introduction
The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004 [PubMed 14613930]).[supplied by OMIM
Entrez Gene ID
9765
UniProt ID
Q7Z3T8
Alternative Names
DKFZp686E13162; ENDOFIN; KIAA0305
Function
May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.
Biological Process
Biological Process endosomal transport Source:UniProtKB1 Publication
Biological Process protein targeting to lysosome Source:UniProtKB1 Publication
Biological Process regulation of endocytosis Source:UniProtKB1 Publication
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process vesicle organization Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Early endosome membrane
Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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