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Mouse Anti-ZFYVE1 Recombinant Antibody (4B2) (CBMAB-Z0241-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4B2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ZFYVE1 (AA1-99) partial recombinant protein with GST tag. Immunogen sequence: MSAQTSPAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH RQERLRNHER IRLKPGHVPY CDLCKGLSGH LPGVRQRAIV RCQTCKINL
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
Zinc Finger FYVE-Type Containing 1
Introduction
ZFYVE1 (Zinc Finger FYVE-Type Containing 1) is a Protein Coding gene. Diseases associated with ZFYVE1 include Syndromic X-Linked Intellectual Disability Snyder Type. Among its related pathways are Autophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding and phosphatidylinositol-3,4-bisphosphate binding.
Entrez Gene ID
53349
UniProt ID
Q9HBF4
Alternative Names
SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172
Function
Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241).
Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241).
Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241).
Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955).
Biological Process
Biological Process cellular response to starvation Source:ParkinsonsUK-UCL1 Publication
Biological Process lipid droplet formation Source:UniProtKB1 Publication
Biological Process macroautophagy Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Golgi apparatus, Golgi stack
Golgi apparatus
Endoplasmic reticulum
Lipid droplet
Preautophagosomal structure
Mitochondrion
Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955).
Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386).
During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663).
Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241).
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For research use only. Not intended for any clinical use.

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