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Mouse Anti-ZFAND6 Antibody (12BA11) (CBMAB-1833CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
12BA11
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ZFAND6
Introduction
ZFAND6 (Zinc Finger AN1-Type Containing 6) involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. It may involved in modulation of Lys-48-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1.
Entrez Gene ID
54469
UniProt ID
Q6FIF0
Alternative Names
AWP1; ZA20D3; ZFAND5B; zinc finger; A20 domain containing 3; AN1-type zinc finger protein 6; protein associated with PRK1; Associated with PRK1 protein; Zinc finger A20 domain-containing protein 3
Function
Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process cellular response to tumor necrosis factor Source:UniProtKB1 Publication
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process protein targeting to peroxisome Source:UniProtKB
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

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