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Mouse Anti-ZBTB48 Monoclonal Antibody (3C4) (CBMAB-0344-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3C4
Antibody Isotype
IgG2b
Application
IP, ELISA, WB

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ZBTB48
Introduction
Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.
Entrez Gene ID
3104
UniProt ID
P10074
Alternative Names
HKR3; ZNF855
Function
Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411).
Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411).
Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411).
Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257).
Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257).
Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177).
Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).
Biological Process
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process telomere maintenance via telomere lengthening Source:UniProtKB2 Publications
Cellular Location
Nucleus
Chromosome, telomere
Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411).
According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411).
According to another report, binds telomeres regardless of their length (PubMed:28500257).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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