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Mouse Anti-ZBTB18 Recombinant Antibody (CBWJZ-177) (CBMAB-Z0437-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-177
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ZNF238 (AA182-281) partial recombinant protein with GST tag. Immunogen sequence: KRDLAAEPGN MWMRLPSDSA GIPQAGGEAE PHATAAGKTV ASPCSSTESL SQRSVTSVRD SADVDCVLDL SVKSSLSGVE NLNSSYFSSQ DVLRSNLVQV
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
ZBTB18
Introduction
ZBTB18 (Zinc Finger And BTB Domain Containing 18) is a Protein Coding gene. Diseases associated with ZBTB18 include Mental Retardation, Autosomal Dominant 22 and Retinitis Pigmentosa 58. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZBTB42.
Entrez Gene ID
10472
UniProt ID
Q99592
Alternative Names
RP58; MRD22; TAZ-1; ZNF238; C2H2-171
Function
Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.
Biological Process
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:CAFA1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process skeletal muscle tissue development Source:UniProtKB
Cellular Location
Nucleus
Associates with condensed chromatin.
Involvement in disease
Intellectual developmental disorder, autosomal dominant 22 (MRD22):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Additional MRD22 patients have limited or no speech, and variable but characteristic facial features, including round face, prominent forehead, flat nasal bridge, hypertelorism, epicanthal folds, and low-set ears. Other features may include hypotonia, poor growth, microcephaly, agenesis of the corpus callosum, and seizures.
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For research use only. Not intended for any clinical use.

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