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Mouse Anti-YWHAG Recombinant Antibody (CBYJT-5593) (CBMAB-T5226-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5593
Antibody Isotype
IgG2a, κ
Application
IF, ELISA, WB

Basic Information

Immunogen
YWHAG (AAH20963, 1 a.a. ~ 247 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-247

Target

Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Introduction
YWHAG belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and YWHAG is 100% identical to the rat ortholog. YWHAG is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. YWHAG has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.
Entrez Gene ID
7532
UniProt ID
P61981
Alternative Names
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Gamma Polypeptide; Protein Phosphatase 1, Regulatory Subunit 170; Protein Kinase C Inhibitor Protein 1; KCIP-1; 14-3-3 Protein Gamma
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Biological Process
Biological Process cellular response to insulin stimulus Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:UniProtKB1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process regulation of neuron differentiation Source:UniProtKB1 Publication
Biological Process regulation of signal transduction Source:UniProtKB2 Publications
Biological Process regulation of synaptic plasticity Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Involvement in disease
Developmental and epileptic encephalopathy 56 (DEE56):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE56 is an autosomal dominant condition.
PTM
Phosphorylated by various PKC isozymes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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