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Mouse Anti-XPO1 Recombinant Antibody (CBFYE-1688) (CBMAB-E2361-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1688
Application
WB, ICC, IHC-P, IHC-F, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
exportin 1
Introduction
XPO1 mediates the export of HOG1 to the cytoplasm of cells adapted to stress.
Entrez Gene ID
7514
UniProt ID
O14980
Alternative Names
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]
Function
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.
(Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Biological Process
Biological Process mRNA transport Source:UniProtKB-KW
Biological Process nucleocytoplasmic transport Source:UniProtKB1 Publication
Biological Process protein export from nucleus Source:UniProtKB1 Publication
Biological Process protein localization to nucleus Source:Ensembl
Biological Process regulation of centrosome duplication Source:Ensembl
Biological Process regulation of proteasomal ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process regulation of protein export from nucleus Source:Ensembl
Biological Process ribosomal large subunit export from nucleus Source:ParkinsonsUK-UCL1 Publication
Biological Process ribosomal small subunit export from nucleus Source:ParkinsonsUK-UCL1 Publication
Biological Process ribosomal subunit export from nucleus Source:ParkinsonsUK-UCL1 Publication
Biological Process ribosome biogenesis Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Cytoplasm
Nucleus, nucleoplasm
Nucleus, Cajal body
Nucleus, nucleolus
Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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