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Mouse Anti-XPA Recombinant Antibody (2A4) (CBMAB-X0138-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2A4
Antibody Isotype
IgG1
Application
WB, IHC, ICC, IF

Basic Information

Immunogen
His-tagged recombinant human XPA protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
XPA, DNA Damage Recognition And Repair Factor
Introduction
XPA is a zinc finger protein, which plays a central role in nucleotide excision repair (NER). XPA interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in XPA cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer.
Entrez Gene ID
7507
UniProt ID
P23025
Alternative Names
XP1; XPAC
Function
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Biological Process
Biological Process base-excision repair Source:GO_Central1 Publication
Biological Process DNA repair Source:CAFA1 Publication
Biological Process nucleotide-excision repair involved in interstrand cross-link repair Source:GO_Central1 Publication
Biological Process nucleotide-excision repair, DNA damage recognition Source:GO_Central1 Publication
Biological Process nucleotide-excision repair, DNA incision Source:CACAO1 Publication
Biological Process protein localization to nucleus Source:CAFA1 Publication
Biological Process UV protection Source:CAFA1 Publication
Biological Process UV-damage excision repair Source:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Xeroderma pigmentosum complementation group A (XP-A):
An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-A patients show the most severe skin symptoms and progressive neurological disorders.
PTM
ATR-dependent phosphorylation of XPA at Ser-196 is important for cell survival in response to UV damage.
Ubiquitinated by HERC2 leading to degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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