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Mouse Anti-XAF1 Recombinant Antibody (CBYCX-110) (CBMAB-X0075-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCX-110
Antibody Isotype
IgG2a, Κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
XIAP Associated Factor 1
Introduction
XAF1 binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. XAF1 seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family and inhibits anti-caspase activity of BIRC4. XAF1 mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. XAF1 may also be a tumor suppressor by mediating apoptosis resistance of cancer cells.
Entrez Gene ID
54739
UniProt ID
Q6GPH4
Alternative Names
BIRC4BP; XIAPAF1; HSXIAPAF1
Function
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process response to interferon-beta Source:BHF-UCL1 Publication
Cellular Location
Cytoplasm
Nucleus
Mitochondrion
Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.
Isoform 1
Nucleus
Isoform 5
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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