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Mouse Anti-WIPF1 Recombinant Antibody (3D10) (CBMAB-W0093-WJ)


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Summary

Host Animal
Mouse
Specificity
Human, Monkey, Mouse
Clone
3D10
Application
Dot, IP, WB

Basic Information

Immunogen
Recombinant protein fragment corresponding to human WIP/WIPF1 at N-terminal, fused to GST-Tag. Species sequence homology: rat.
Specificity
Human, Monkey, Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WAS/WASL interacting protein family, member 1
Introduction
WIPF1 is a protein-coding gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. This protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Diseases associated with WIPF1 include Wiskott-Aldrich Syndrome 2 and Wiskott-Aldrich Syndrome. Gene Ontology (GO) annotations related to this gene include actin binding and profilin binding.
Entrez Gene ID
Human7456
Mouse215280
Monkey698446
UniProt ID
HumanO43516
MouseQ8K1I7
MonkeyF7ACR6
Alternative Names
WAS/WASL interacting protein family member 1
Function
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity).
Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
Biological Process
Biological Process actin filament-based movement Source:GO_Central1 Publication
Biological Process actin polymerization or depolymerization Source:ProtInc1 Publication
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process response to other organism Source:Ensembl
Cellular Location
Cytoplasmic vesicle
Cytoplasm, cytoskeleton
Cell projection, ruffle
Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity).
Involvement in disease
Wiskott-Aldrich syndrome 2 (WAS2):
An immunodeficiency disorder characterized by eczema, thrombocytopenia, recurrent infections, defective T-cell proliferation, and impaired natural killer cell function.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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