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Mouse Anti-WDR77 Recombinant Antibody (CBWJW-016) (CBMAB-W0173-WJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJW-016
Application
WB, ICC

Basic Information

Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD Repeat Domain 77
Introduction
WDR77 is a protein-coding gene encodes the protein which is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. It may be involved in the early stages of prostate cancer. Among its related pathways are Gene Expression and Chromatin organization.
Entrez Gene ID
Human79084
Mouse70465
Rat310769
UniProt ID
HumanQ9BQA1
MouseQ99J09
RatQ4QR85
Alternative Names
p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50
Function
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452).
This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).
Biological Process
Biological Process epithelial cell proliferation involved in prostate gland development Source:Ensembl
Biological Process histone H4-R3 methylation Source:ComplexPortal1 Publication
Biological Process negative regulation of epithelial cell proliferation involved in prostate gland development Source:Ensembl
Biological Process oocyte axis specification Source:GO_Central1 Publication
Biological Process positive regulation of cell population proliferation Source:Ensembl
Biological Process positive regulation of mRNA splicing, via spliceosome Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source:Ensembl
Biological Process spliceosomal snRNP assembly Source:ComplexPortal1 Publication
Cellular Location
Nucleus
Cytoplasm
Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors (PubMed:17437848).
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For research use only. Not intended for any clinical use.

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