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Mouse Anti-WDR36 Recombinant Antibody (1D6) (CBMAB-W0037-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D6
Antibody Isotype
IgG2a, к
Application
ELISA, WB

Basic Information

Immunogen
WDR36 (NP_644810, aa853-951) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: SGIETELRSL SPDCGGSIEV MQSFLKMIGM MLDRKRDFEL AQAYLALFLK LHLKMLPSEP VLLEEITNLS SQVEENWTHL QSLFNQSMCI LNYLKSALL
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD repeat domain 36
Introduction
WDR36 is a protein-coding gene encodes a member of the WD repeat protein family. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Diseases associated with WDR36 include Glaucoma 1, Open Angle, G and Open-Angle Glaucoma. The related pathways are Gene Expression and rRNA processing in the nucleus and cytosol.
Entrez Gene ID
134430
UniProt ID
Q8NI36
Alternative Names
GLC1G; UTP21; TAWDRP; TA-WDRP
Function
Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.
Biological Process
Biological Process response to stimulus Source:UniProtKB-KW
Biological Process rRNA processing Source:GO_Central1 Publication
Biological Process visual perception Source:UniProtKB-KW
Cellular Location
Nucleus, nucleolus
Involvement in disease
Glaucoma 1, open angle, G (GLC1G):
A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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