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Mouse Anti-VTI1B Recombinant Antibody (CBYCV-133) (CBMAB-V0097-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYCV-133
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Mouse Vti1b aa 9-121
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 9-121

Target

Full Name
Vesicle Transport Through Interaction With T-SNAREs 1B
Introduction
Diseases associated with VTI1B include Hypomyelinating Leukodystrophy. Among its related pathways are wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF) and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotationsshow that VTI1B is related to SNARE binding and chloride channel inhibitor activity. An important paralog of this gene is VTI1A.
Entrez Gene ID
Human10490
Mouse53612
Rat100359512
UniProt ID
HumanQ9UEU0
MouseO88384
RatP58200
Alternative Names
Vesicle Transport Through Interaction With T-SNAREs 1B; Vesicle Transport V-SNARE Protein Vti1-Like 1; Vti1-Rp1; VTI1L; VTI1; VTI2; Vesicle Transport Through Interaction With T-SNAREs Homolog 1B (Yeast)
Function
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
Biological Process
Biological Process Golgi to vacuole transport Source:GO_Central1 Publication
Biological Process intra-Golgi vesicle-mediated transport Source:GO_Central1 Publication
Biological Process intracellular protein transport Source:InterPro
Biological Process macroautophagy Source:GO_Central1 Publication
Biological Process membrane fusion Source:ProtInc1 Publication
Biological Process regulation of protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process retrograde transport, endosome to Golgi Source:GO_Central1 Publication
Biological Process vesicle docking involved in exocytosis Source:ProtInc1 Publication
Biological Process vesicle fusion Source:GO_Central1 Publication
Biological Process vesicle fusion with Golgi apparatus Source:GO_Central1 Publication
Biological Process vesicle-mediated transport Source:ProtInc1 Publication
Cellular Location
Early endosome membrane
Late endosome membrane
Lysosome membrane
Cytoplasmic granule
Recycling endosome membrane
Topology
Cytoplasmic: 2-208
Helical: 209-229
Vesicular: 230-232
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For research use only. Not intended for any clinical use.

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