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Mouse Anti-VTI1A Recombinant Antibody (1E3) (CBMAB-V0096-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E3
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human VTI1A(NP_660207) produced in HEK293T cell.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Vesicle Transport Through Interaction With T-SNAREs 1A
Introduction
VTI1A is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in VTI1A have been associated with binocular function, and also with susceptibility to colorectal and lung cancers.
Entrez Gene ID
143187
UniProt ID
Q96AJ9
Alternative Names
Vesicle Transport Through Interaction With T-SNAREs 1A; Vesicle Transport V-SNARE Protein Vti1-Like 2; Vti1-Rp2; Vesicle Transport Through Interaction With T-SNAREs Homolog 1A (Yeast); Vesicle Transport Through Interaction With T-SNAREs Homolog 1A; SNARE Vti1a-Beta Protein; VTI1RP2; MMDS3; MVti1
Function
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.
Biological Process
Biological Process autophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process endocytic recycling Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:ParkinsonsUK-UCL
Biological Process Golgi to vacuole transport Source:GO_Central1 Publication
Biological Process intra-Golgi vesicle-mediated transport Source:GO_Central1 Publication
Biological Process intracellular protein transport Source:InterPro
Biological Process macroautophagy Source:GO_Central1 Publication
Biological Process retrograde transport, endosome to Golgi Source:UniProtKB1 Publication
Biological Process vesicle fusion Source:GO_Central1 Publication
Biological Process vesicle fusion with Golgi apparatus Source:ParkinsonsUK-UCL
Biological Process voluntary musculoskeletal movement Source:UniProtKB1 Publication
Cellular Location
Cytoplasmic vesicle
Golgi apparatus membrane
Topology
Cytoplasmic: 1-192
Helical: 193-213
Extracellular: 214-217
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For research use only. Not intended for any clinical use.

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