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Mouse Anti-VPS25 Recombinant Antibody (2E5-2B9) (CBMAB-V0006-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E5-2B9
Antibody Isotype
IgG1, к
Application
ELISA, IF, WB

Basic Information

Immunogen
MGC10540 (aa H06282, aa 1-176) full-length recombinant protein with GST tag. Immunogen sequence: MAMSFEWPWQ YRFPPFFTLQ PNVDTRQKQL AAWCSLVLSF CRLHKQSSMT VMEAQESPLF NNVKLQRKLP VESIQIVLEE LRKKGNLEWL DKSKSSFLIM WRRPEEWGKL IYQWVSRSGQ NNSVFTLYEL TNGEDTEDEE FHGLDEATLL RALQALQQEH KAEIITVSDG RGVKFF
Specificity
Human
Antibody Isotype
IgG1, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-176

Target

Full Name
vacuolar protein sorting 25 homolog (S. cerevisiae)
Introduction
VPS25 is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). The complex functions in sorting of ubiquitinated membrane proteins during endocytosis.
Entrez Gene ID
84313
UniProt ID
Q9BRG1
Alternative Names
Vacuolar Protein Sorting 25 Homolog; Dermal Papilla-Derived Protein 9; ELL-Associated Protein Of 20 KDa; ESCRT-II Complex Subunit VPS25; DERP9; EAP20
Function
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.
Biological Process
Biological Process macroautophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process membrane fission Source:ComplexPortal1 Publication
Biological Process multivesicular body assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of epidermal growth factor-activated receptor activity Source:UniProtKB1 Publication
Biological Process protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Endosome membrane
Nucleus, nucleoplasm
Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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