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Mouse Anti-VCAN Recombinant Antibody (5H26) (CBMAB-C7720-LY)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
5H26
Antibody Isotype
IgG1
Application
IHC-F, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1592-2222 of Chondroitin Sulfate Proteoglycan expressed as a truncated integral membrane form in HEK293 cells. Species Sequence Homology: mouse
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
30% glycerol
Preservative
0.05% sodium azide
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
VCAN
Introduction
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Entrez Gene ID
114122
UniProt ID
Q9ERB4
Function
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Biological Process
Biological Process cell adhesion Source:ProtInc1 Publication
Biological Process cell recognition Source:ProtInc1 Publication
Biological Process central nervous system development Source:GO_Central1 Publication
Biological Process glial cell migration Source:BHF-UCL
Biological Process osteoblast differentiation Source:UniProtKB1 Publication
Biological Process skeletal system development Source:GO_Central1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
Cell projection, cilium, photoreceptor outer segment
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix
Involvement in disease
Wagner vitreoretinopathy (WGVRP):
A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia.
PTM
Phosphorylated by FAM20C in the extracellular medium.
Proteolytically cleaved by ADAMTS5 and ADAMTS15 in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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