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Mouse Anti-VCAM1 Recombinant Antibody (CBYY-1337) (CBMAB-1372-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1337
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
LPS activated HUVECs
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Vascular Cell Adhesion Molecule 1
Introduction
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforMouse have been described for this gene.
Entrez Gene ID
7412
UniProt ID
P19320
Alternative Names
Vascular Cell Adhesion Molecule 1; CD106 Antigen; INCAM-100; Vascular Cell Adhesion Protein 1; V-CAM 1; VCAM-1; CD106;
Function
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Biological Process
Biological Process acute inflammatory response Source:Ensembl
Biological Process aging Source:Ensembl
Biological Process amine metabolic process Source:UniProtKB1 Publication
Biological Process B cell differentiation Source:BHF-UCL1 Publication
Biological Process calcium-mediated signaling using intracellular calcium Source Source:UniProtKB1 Publication
Biological Process cardiac neuron differentiation Source:Ensembl
Biological Process cell adhesion Source:BHF-UCL1 Publication
Biological Process cell chemotaxis Source:Ensembl
Biological Process cell-cell adhesion in response to extracellular stimulus Source:ARUK-UCL1 Publication
Biological Process cell-matrix adhesion Source:UniProtKB1 Publication
Biological Process cellular response to amyloid-beta Source:ARUK-UCL1 Publication
Biological Process cellular response to tumor necrosis factor Source:Ensembl
Biological Process cellular response to vascular endothelial growth factor stimulus Source:Ensembl
Biological Process chronic inflammatory response Source:Ensembl
Biological Process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source:BHF-UCL1 Publication
Biological Process heterotypic cell-cell adhesion Source:ARUK-UCL1 Publication
Biological Process innervation Source:Ensembl
Biological Process leukocyte cell-cell adhesion Source:BHF-UCL3 Publications
Biological Process leukocyte tethering or rolling Source:UniProtKB1 Publication
Biological Process membrane to membrane docking Source:BHF-UCL1 Publication
Biological Process positive regulation of T cell proliferation Source:BHF-UCL1 Publication
Biological Process response to ethanol Source:Ensembl
Biological Process response to hypoxia Source:Ensembl
Biological Process response to ionizing radiation Source:Ensembl
Biological Process response to lipopolysaccharide Source:Ensembl
Biological Process response to nicotine Source:Ensembl
Biological Process response to nutrient Source:Ensembl
Biological Process response to zinc ion Source:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 25-698
Helical: 699-720
Cytoplasmic: 721-739
PTM
Sialoglycoprotein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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