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Mouse Anti-VBP1 Recombinant Antibody (2G2) (CBMAB-P3774-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Dog, Monkey
Clone
2G2
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human, Mouse, Rat, Dog, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
von Hippel-Lindau binding protein 1
Introduction
VBP1 interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms.
Entrez Gene ID
Human7411
Mouse22327
Rat681825
Dog481089
Monkey114669754
UniProt ID
HumanP61758
MouseP61759
DogA0A8C0THF8
MonkeyF6WUT9
Alternative Names
VHL Binding Protein 1; Von Hippel-Lindau Binding Protein 1; HIBBJ46; PFDN3; VBP-1; Von Hippel-Lindau-Binding Protein 1;
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Biological Process
Biological Process microtubule-based process Source:GO_Central1 Publication
Biological Process negative regulation of amyloid fibril formation Source:FlyBase1 Publication
Biological Process protein folding Source:FlyBase1 Publication
Biological Process protein stabilization Source:ComplexPortal1 Publication
Biological Process tubulin complex assembly Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
In complex with VHL can translocate to the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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