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Mouse Anti-USP30 Recombinant Antibody (CBXU-013) (CBMAB-U0129-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXU-013
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin specific peptidase 30
Introduction
USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).
Entrez Gene ID
84749
UniProt ID
Q70CQ3
Alternative Names
USP30; ubiquitin specific peptidase 30; ubiquitin specific protease 30; ubiquitin carboxyl-terminal hydrolase 30; FLJ40511; MGC10702; ub-specific protease 30; ubiquitin thioesterase 30; deubiquitinating enzyme 30
Function
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951).
Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951).
Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291).
Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).
Biological Process
Biological Process autophagy of mitochondrion Source:UniProtKB1 Publication
Biological Process mitochondrial fusion Source:UniProtKB
Biological Process negative regulation of mitophagy Source:Ensembl
Biological Process pexophagy Source:Reactome
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process protein K11-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein K6-linked deubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Mitochondrion outer membrane
Topology
Mitochondrial intermembrane: 1-35
Helical: 36-56
Cytoplasmic: 57-517
PTM
Ubiquitinated by parkin (PRKN) at Lys-235 and Lys-289, leading to its degradation.
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For research use only. Not intended for any clinical use.

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