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Mouse Anti-UBR3 Recombinant Antibody (5A10) (CBMAB-A10211-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5A10
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
ZNF650 (NP_742067, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ubiquitin Protein Ligase E3 Component N-Recognin 3 (Putative)
Entrez Gene ID
130507
UniProt ID
Q6ZT12
Alternative Names
DKFZp434P117; DKFZp686N10185; FLJ37422; KIAA2024; MGC126489; ZNF650
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity).
Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).
May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity).
May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610).
Biological Process
Biological Process embryo development ending in birth or egg hatching Source:UniProtKB
Biological Process negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source:Ensembl
Biological Process positive regulation of protein catabolic process Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process sensory perception of smell Source:UniProtKB
Biological Process suckling behavior Source:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process via the N-end rule pathway Source:GO_Central1 Publication
Cellular Location
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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