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Mouse Anti-UBR2 Recombinant Antibody (4G4) (CBMAB-A9746-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
UBR2 (NP_056070, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
UBR2
Introduction
Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM
Entrez Gene ID
23304
UniProt ID
Q8IWV8
Alternative Names
C6orf133; DKFZp686C08114; KIAA0349; MGC71112; RP3-392M17.3; bA49A4.1; dJ242G1.1; dJ392M17.3
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242).
Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).
Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity).
Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436).
Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity).
Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity).
Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity).
Biological Process
Biological Process cellular response to leucine Source:UniProtKB1 Publication
Biological Process heterochromatin formation Source:UniProtKB
Biological Process histone H2A ubiquitination Source:UniProtKB
Biological Process male meiosis I Source:Ensembl
Biological Process male meiotic nuclear division Source:UniProtKB
Biological Process negative regulation of TOR signaling Source:UniProtKB1 Publication
Biological Process negative regulation of transposition Source:UniProtKB
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process reciprocal meiotic recombination Source:UniProtKB
Biological Process spermatogenesis Source:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process via the N-end rule pathway Source:GO_Central1 Publication
Cellular Location
Nucleus
Chromosome
Associated with chromatin during meiosis.
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For research use only. Not intended for any clinical use.

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