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Mouse Anti-UBP1 Recombinant Antibody (CBFYU-203) (CBMAB-U0203-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-203
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 47-269 of human UBP1(NP_055332) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS(pH 7.3) containing 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 47-269

Target

Full Name
upstream binding protein 1 (LBP-1a)
Introduction
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2.
Entrez Gene ID
7342
UniProt ID
Q9NZI7
Alternative Names
LBP-1a
Function
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335).
Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293).
Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
Biological Process
Biological Process DNA repair Source:UniProtKB-KW
Biological Process monoubiquitinated protein deubiquitination Source:UniProtKB1 Publication
Biological Process positive regulation of error-prone translesion synthesis Source:Reactome
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of DNA repair Source:UniProtKB1 Publication
Biological Process response to UV Source:UniProtKB1 Publication
Biological Process skeletal system development Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
PTM
Autocatalytic cleavage of USP1 following UV irradiation inactivates it, leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment
Ubiquitinated by the CRL2(KLHDC2) complex following autocatalytic cleavage, leading to its degradation: the CRL2(KLHDC2) complex recognizes the diglycine (Gly-Gly) at the C-terminus.
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For research use only. Not intended for any clinical use.

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