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Mouse Anti-UBE4B Recombinant Antibody (CBFYU-176) (CBMAB-U0176-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-176
Antibody Isotype
IgG2a, к
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 kD. Immunogen sequence: FKLLAEKVEE IVAKNARAEI DYSDAPDEFR DPLMDTLMTD PVRLPSGTIM DRSIILRHLL NSPTDPFNRQ TLTESMLEPV PELKEQIQAW MREKQNSDH.
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1075-1173

Target

Full Name
ubiquitination factor E4B (UFD2 homolog, yeast)
Introduction
This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Entrez Gene ID
10277
UniProt ID
O95155
Alternative Names
E4; UFD2; HDNB1; UBOX3; UFD2A
Function
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity).
May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity).
May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820).
Biological Process
Biological Process granzyme-mediated apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:MGI1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process response to UV Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
PTM
Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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